Effect of Gen (HLA-DR4) on Reumatoide Arthrites In Wasit Province \ Iraq

Author(s): Zahra Karem Hady1, Haider Hafudh Humaish2
Date: 09/10/2026
doi: https://doi.org/10.5281/zenodo.8425890

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Abstract

Rheumatoid arthritis (RA) is a multifaceted inflammatory disease with a significant hereditary component 
to its pathophysiology. Most of the population is vulnerable to this illness due to genetic factors. 
Predisposition to RA has been demonstrated to be influenced by genetic variables. Human Leukocyte 
Antigen –DR isotype 4system is a gene complex in humans that encodes cell-surface proteins responsible 
for the regulation of the immune system. HLA-DR is a class of cell-surface receptors encoded for by the 
HLA system. 90 subjects of both genders were collected, including 60 patients and 30 from the control 
group. The results showed that the mean  levels was lower in RA patients in compared to healthy control 
and the difference was highly significant (P < 0.001). The studied genome contribute as indicators of the 
development of health risks to the body and Reumatoide Arthrites  health and patients. 

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