Relationship Between Obesity, Oxidative Stress, and Endothelial Function in Iraqi Young Adults: A Cross-Sectional Study at Al Sadr Teaching Hospital, Najaf

Author(s): Saja Nabeel Taqi
Date: 08/10/2026
doi: https://doi.org/10.5281/zenodo.8425890

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Abstract

Background: Obesity among young Iraqis is increasing drastically, and it has been recognized as a 
chronic state of oxidative stress that may predispose individuals to cardio vascular diseases. Oxidative 
stress reduces nitric oxide bioavailability, which may be a mechanism by which obesity leads to 
endothelial dysfunction. However, studies involving young Iraqis have been limited. 
Aim of study: The purpose of the study was to investigate the correlation between obesity and oxidative 
stress biomarkers in addition to endothelial functions among young Iraqi adults. 
Methodology: This study used a cross-sectional descriptive design over a three-month period from 
February to April at Al-Sadr Teaching Hospital in Najaf, Iraq. Respondents were aged between 18 and 35 
years, with individuals with Body Mass Index above 30 categorised as obese in comparison to normal 
controls. 
Results: Findings suggest that participants within the obese group exhibited higher serum MDA levels 
plus lesser levels of TAC along with reduced flow-mediated dilation in comparison to non-obese controls. 
There was negative correlation between MDA and FMD, while MDA showed a statistically significant 
positive relation with TAC. 
Conclusion: Participants who were obese exhibited increased levels of oxidative stress, thereby 
confirming the importance of preventive measures and lifestyles interventions within this young Iraqi 
population.

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