Serological and Metabolic Test Correlates of Coxsackievirus B Infection in Iraqi Children with Type 1 Diabetes

Author(s): Diyar F. Murad¹, zahraa fawwaz faraj1, Athraa Shakir Khozan¹, Anwar Ibraheem Faisal¹, Hawraa Kareem Mohammed¹
Date: 08/10/2026
doi: https://doi.org/10.5281/zenodo.8425890

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Abstract

The autoimmune condition identified as type 1 diabetes mellitus (T1DM) has been associated to the death 
of pancreatic β-cells.  In this study, Iraqi children with type 1 diabetes had their metabolic and serological 
signs of CVB infection evaluated. Techniques:  From the end of 2023 to the beginning of 2024, Al
Diwaniyah Teaching Hospital carried out a case-control study.  56 youngsters with T1DM who received 
clinical diagnoses between the ages of 3 and 15 were included.  qRT-PCR targeting VP1 was used to 
detect CVB RNA.  Enzymatic and HPLC techniques were used for calculating glycated hemoglobin 
(HbA1c), random blood sugar (RBS), and fasting serum glucose (FSG). ELISA was used to identify anti
glutamic acid decarboxylase (anti-GAD) antibodies.  

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