Article Review: Histopathological Change in Tissue After Injectable Hyaluronic Acid (Dermal Filler)

Author(s): Asawer Abdul-Jabbar Al-Salman
Date: 08/10/2026
doi: https://doi.org/10.5281/zenodo.8425890

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Abstract

Injectable fillers in the current times are now a pillar in facial rejuvenation and play a key role in ensuring 
the success of the treatment. Although their advantages are undeniable, the list of potential complications 
(adverse effects that are instant, late, delayed, transient or irreversible) is too long and must be taken into 
consideration. The distinction is made between the different filler material, these effects are attributed to 
findings of the histopathology and to the existing treatment options. 
Background 
Injectable hyaluronic acid is one of the temporary dermal fillers. The concentration of hyaluronic acid can 
be found naturally in all parts of the body with the highest concentration found in the joints, eyes and the 
skin. Hyaluronic acid injected is intended to minimize the effect of fine lines, wrinkles, folds of the face, 
structure, framework, and volume of the face and lips. 
Aims: In order to assess the degradation and alterations within the tissue after hyaluronic acid (HA) filler 
injections with special attention paid to crosslinking agents, degradation and tissue reactions.. 

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